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Chronic Obstructive Pulmonary Disease Biomarkers [Eurasian J Pulmonol]
Eurasian J Pulmonol. 2016; 18(1): 3-10 | DOI: 10.5152/ejp.2015.02411  

Chronic Obstructive Pulmonary Disease Biomarkers

Tatsiana Beiko, Charlie Strange
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America

Despite significant decreases in morbidity and mortality of cardiovascular diseases (CVD) and cancers, morbidity and cost associated with chronic obstructive pulmonary disease (COPD) continue to be increasing. Failure to improve disease outcomes has been related to the paucity of interventions improving survival. Insidious onset and slow progression halter research successes in developing disease-modifying therapies. In part, the difficulty in finding new therapies is because of the extreme heterogeneity within recognized COPD phenotypes. Novel biomarkers are necessary to help understand the natural history and pathogenesis of the different COPD subtypes. A more accurate phenotyping and the ability to assess the therapeutic response to new interventions and pharmaceutical agents may improve the statistical power of longitudinal clinical studies. In this study, we will review known candidate biomarkers for COPD, proposed pathways of pathogenesis, and future directions in the field.

Keywords: Biomarker, chronic obstructive pulmonary disease, emphysema, fibrinogen, smoking

Tatsiana Beiko, Charlie Strange. Chronic Obstructive Pulmonary Disease Biomarkers. Eurasian J Pulmonol. 2016; 18(1): 3-10

Corresponding Author: Tatsiana Beiko, United States

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