c-erb B-2 oncogene protein expression in lung cancer

SALEPC�, Banu; �ZDEM�R, Nagehan; �ZDO�AN, Sevda; KIRAL, Nesrin; SALEPC�, Ta�an; �A�ALAYAN, Benan

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c-erb B-2 oncogene protein expression in lung cancer [Eurasian J Pulmonol]

Eurasian J Pulmonol. 2001; 3(3): 121-125

c-erb B-2 oncogene protein expression in lung cancer

Banu SALEPC�¹, Nagehan �ZDEM�R², Sevda �ZDO�AN¹, Nesrin KIRAL¹, Ta�an SALEPC�³, Benan �A�ALAYAN¹
¹Kartal E�itim ve Ara�t�rma Hastanesi, G��s Hastal�klar� ve T�berk�loz Klini�i, �stanbul
²Kartal E�itim ve Ara�t�rma Hastanesi Patoloji Klini�i, �stanbul
³Kartal E�itim ve Ara�t�rma Hastanesi Medikal Onkoloji Klini�i, �stanbul

We evaluated c-erbB-2 expression in 51 lung cancer patients who were examined in Kartal Educational and Research Hospital Chest Diseases Department in 1996- 99. Pathologic diagnosis was based on tissue biopsy material. The aim of the study was also to evaluate the correlation of histologic type, grade and stage of the tumour with c-erbB-2 expression. 56.8% of 44 nonsmall cell cancer patients had c-erbB-2 overexpression detected by immunohistochemical staining in biopsy specimens. In 7 small cell lung cancer patients there were no positive results. There were no correlation with c-erbB-2 positivity and clinic staging. Grading was available in 41 out of 44 nonsmall cell lung cancer specimens and a correlation of the tumour grade with c-erbB-2 expression could not be detected. Squamous cell lung cancer group which was the largest population of the total patients was divided into two as; operable and inoperable stage. There were no significant difference in c-erbB-2 positivity between these two groups. Our results confirm the previous reports on this topic that c-erbB-2 expression is more frequent in nonsmall cell group of the lung cancer patients and there is no correlation between c-erbB-2 positivity and clinical stage or the histologic grade of the tumour.

Keywords: Lung cancer, c-erbB-2, HER-2 / neu

Akci�er kanseri hastalar�nda c-erbB-2 onkogen ekspresyonu

Kartal E�itim ve Ara�t�rma Hastanesi G��s Hastal�klar� Klini�inde 1996-99 y�llar� aras�nda doku biyopsi �rnekleri ile akci�er kanseri tan�s� konan 51 hastada c-erbB-2 ekspresyonu ve bunun t�m�r�n histolojik tipi, grade'i ve evresi ile ili�kisini ara�t�rmak amac�yla bu �al��ma planland�. K��k h�creli d�� akci�er karsinomu olan 44 hastan�n %56.8'inde c-erbB-2 ekspresyonu imm�nhistokimyasal y�ntemle, dokuda pozitif saptan�rken, 7 k��k h�creli akci�er kanseri hastas�n�n hepsinde negatifti. Vakalarda c-erbB-2 ekspresyonu ile klinik evre aras�nda istatistiki anlaml� ili�ki bulunamad�. K��k h�creli d�� akci�er karsinomu olan 44 hastan�n 41'inde grade tayini yap�labildi. C-erb-2 poziti�i�i ile t�m�r grade'leri aras�nda da istatistiki anlaml� ili�ki bulunamad�. Yine k��k h�creli d�� olup en b�y�k hasta grubunu olu�turan skuamoz h�creli karsinomlar operabl ve inoperabl evrede olan hastalar olarak iki gruba ayr�ld� ve bunlar aras�nda da c-erb B-2 ekspresyonu a��s�ndan anlaml� farkl�l�k yoktu. Bu bulgular�n ve konu ile ilgili daha �nce yap�lan �al��malar�n �� alt�nda akci�er karsinomlar�nda cerbB- 2 ekspresyonunun k��k h�creli d�� akci�er kanserinde daha y�ksek oranlarda bulundu�u ve bunun t�m�r grade'i ve hastalar�n klinik evresiyle bir ili�kisinin bulunmad�� kanaatine var�ld�.

Anahtar Kelimeler: Akci�er kanseri, c-erbB-2, HER-2 / neu

Banu SALEPC�, Nagehan �ZDEM�R, Sevda �ZDO�AN, Nesrin KIRAL, Ta�an SALEPC�, Benan �A�ALAYAN. c-erb B-2 oncogene protein expression in lung cancer. Eurasian J Pulmonol. 2001; 3(3): 121-125

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