Type 2 Respiratory Insufficiency, Pulmonary Hypertension, and Obstructive Sleep Apnea Syndrome that Developed in Morquio SyndromePınar Yıldız Gülhan, Aydanur Ekici, Mehmet Ekici, Dilay ÇimenDepartment of Pulmonary Medicine, Kırıkkale University Faculty of Medicine, Kırıkkale
Mucopolysaccharidosis type IVA (Morquio syndrome) is a multisystemic autosomal recessive transitive disease induced by an N- acetylgalactosamine 6 sulfatase (GALNS) gene defect, progressing with lysosomal stock failure. The accumulation of chondroitin 6 sulfate and keratin sulfate is observed in the tissues due to GALNS deficiency. We presented a case in which Morquio syndrome was successfully treated with noninvasive mechanical ventilation in accordance with the literature. The case had obstructive sleep apnea syndrome (OSAS) induced by an obstruction that emerged as a result of type 2 respiratory insufficiency resulting from throcal deformity, inspiratory muscle weakness, pulmonary hypertension, and the accumulation of diffuse mucopolysaccharide in the upper respiratory tract. Keywords: Morquio syndrome, respiratory insufficiency, sleep apnea
Pınar Yıldız Gülhan, Aydanur Ekici, Mehmet Ekici, Dilay Çimen. Type 2 Respiratory Insufficiency, Pulmonary Hypertension, and Obstructive Sleep Apnea Syndrome that Developed in Morquio Syndrome. Eurasian J Pulmonol. 2014; 16(3): 192-194
Corresponding Author: Pınar Yıldız Gülhan, Türkiye |
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